Products

Western Blot (Cell lysate)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Entrez GeneID

Protein Accession#

Gene Name

PLIN3

Gene Alias

MGC11117, MGC2012, PP17, TIP47, M6PRBP1

Gene Description

mannose-6-phosphate receptor binding protein 1

Omim ID

Gene Ontology

Gene Summary

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene

Other Designations

MPR-BINDING PROTEIN, 47-KD|MPR-binding protein 47 kDa|cargo selection protein (mannose 6 phosphate receptor binding protein)|cargo selection protein TIP47|mannose 6 phosphate receptor binding protein 1|placental protein 17|tail-interacting protein, 47 kD