TANK polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TANK.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human TANK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TANK in Daudi cell lysate with TANK polyclonal antibody (Cat # PAB13214) at (A) 0.5 and (B) 1 ug/mL .Immunocytochemistry
Immunocytochemical staining of Daudi cells with 2.5 ug/mL TANK polyclonal antibody (Cat # PAB13214). -
Gene Info — TANK
Entrez GeneID
10010Protein Accession#
NP_004171Gene Name
TANK
Gene Alias
I-TRAF, TRAF2
Gene Description
TRAF family member-associated NFKB activator
Omim ID
603893Gene Ontology
HyperlinkGene Summary
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
TRAF family member-associated NF-KAPPA-B activator|TRAF interacting protein TANK
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Interactome
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Disease
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Publication Reference
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Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U.
The Journal of Biological Chemistry 2002 Jul; 277(40):37029.
Application:IP, Human, HEK 293 cells.
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NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Pomerantz JL, Baltimore D.
The EMBO Journal 1999 Dec; 18(23):6694.
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TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.
Cheng G, Baltimore D.
Genes & Development 1996 Apr; 10(8):963.
Application:IP, Human, HEK 293 cells.
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Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
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