BCL2A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of BCL2A1 in human kidney tissue lysate with BCL2A1 polyclonal antibody (Cat # PAB13211) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BCL2A1 in mouse kidney tissue with BCL2A1 polyclonal antibody (Cat # PAB13211) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2A1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human BCL2A1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BCL2A1 in human kidney tissue lysate with BCL2A1 polyclonal antibody (Cat # PAB13211) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BCL2A1 in mouse kidney tissue with BCL2A1 polyclonal antibody (Cat # PAB13211) at 10 ug/mL . -
Gene Info — BCL2A1
Entrez GeneID
597Protein Accession#
NP_004040Gene Name
BCL2A1
Gene Alias
ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1
Gene Description
BCL2-related protein A1
Omim ID
601056Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
hematopoietic BCL2-related protein A1
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Interactome
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Pathway
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Disease
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Publication Reference
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Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line.
Kim JK, Kim KD, Lee E, Lim JS, Cho HJ, Yoon HK, Cho MY, Baek KE, Park YP, Paik SG, Choe YK, Lee HG.
Cancer Letters 2004 Aug; 212(1):61.
Application：WB, Human, T24, T24R2 cells.
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Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.
Cell Death and Differentiation 2000 Jan; 7(1):2.
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A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.
Choi SS, Park IC, Yun JW, Sung YC, Hong SI, Shin HS.
Oncogene 1995 Nov; 11(9):1693.
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Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line.
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