BAG1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BAG1.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human BAG1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BAG1 in PC-3 cell lysate with BAG1 polyclonal antibody (Cat # PAB13210) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BAG1 in human lymph node tissue with BAG1 polyclonal antibody (Cat # PAB13210) at 2 ug/mL -
Gene Info — BAG1
Entrez GeneID
573Protein Accession#
NP_004314Gene Name
BAG1
Gene Alias
RAP46
Gene Description
BCL2-associated athanogene
Omim ID
601497Gene Ontology
HyperlinkGene Summary
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site, and alternative, downstream, AUG translation initiation sites. [provided by RefSeq
Other Designations
BCL2-associated athanogene 1
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Interactome
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Disease
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Publication Reference
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Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers.
Krajewska M, Turner BC, Shabaik A, Krajewski S, Reed JC.
Prostate 2006 Jun; 66(8):801.
Application:IHC-P, Human, Human prostate carcinoma.
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BAG-1 family of cochaperones in the modulation of nuclear receptor action.
Cato AC, Mink S.
The Journal of Steroid Biochemistry and Molecular Biology 2001 Nov; 78(5):379.
Application:IHC, WB-Tr, Human, Yeast, Human cervical cancer, Mammalian, Yeast cells.
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Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity.
Nollen EA, Brunsting JF, Song J, Kampinga HH, Morimoto RI.
Molecular and Cellular Biology 2000 Feb; 20(3):1083.
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Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers.
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