UNG polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UNG.
Immunogen
A synthetic peptide corresponding to N-terminus 13 amino acids of human UNG.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of UNG in C2C12 cell lysate with UNG polyclonal antibody (Cat # PAB13208) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of UNG in human heart tissue with UNG polyclonal antibody (Cat # PAB13208) at 2 ug/mL . -
Gene Info — UNG
Entrez GeneID
7374Protein Accession#
NP_003353Gene Name
UNG
Gene Alias
DGU, DKFZp781L1143, HIGM4, UDG, UNG1, UNG15, UNG2
Gene Description
uracil-DNA glycosylase
Gene Ontology
HyperlinkGene Summary
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq
Other Designations
uracil-DNA glycosylase 1, uracil-DNA glycosylase 2|uracil-DNA glycosylase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.
Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC, Bohr VA.
Neurobiology of Aging 2006 Aug; 27(8):1129.
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Base excision repair.
Fromme JC, Verdine GL.
Advances in Protein Chemistry 2004 Dec; 69:1.
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Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic.
Kachhap S, Singh KK.
Molecular Cancer 2004 Dec; 3:32.
Application:WB-Tr, Human, MCF12A cells.
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Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.
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