IL27 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of IL27 in EL4 lysate with IL27 polyclonal antibody (Cat # PAB13199) at (A) 2 and (B) 4 ug/mL .
Immunocytochemistry
Immunocytochemistry of IL27 in EL4 with IL27 polyclonal antibody (Cat # PAB13199) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IL27.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human IL27.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IL27 in EL4 lysate with IL27 polyclonal antibody (Cat # PAB13199) at (A) 2 and (B) 4 ug/mL .Immunocytochemistry
Immunocytochemistry of IL27 in EL4 with IL27 polyclonal antibody (Cat # PAB13199) at 10 ug/mL . -
Gene Info — IL27
Entrez GeneID
246778Protein Accession#
NP_663634Gene Name
IL27
Gene Alias
IL-27, IL-27A, IL27p28, IL30, MGC71873, p28
Gene Description
interleukin 27
Omim ID
608273Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq
Other Designations
IL-27 p28 subunit|OTTHUMP00000122516|interleukin 30|interleukin-27 subunit alpha
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Disease
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Publication Reference
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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
Hunter CA.
Nature Reviews. Immunology 2005 Jul; 5(7):521.
Application：ELISA, Human, Mouse, T cells.
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WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.
Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.
Journal of Immunology 2004 Feb; 172(4):2225.
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Potent antitumor activity of interleukin-27.
Hisada M, Kamiya S, Fujita K, Belladonna ML, Aoki T, Koyanagi Y, Mizuguchi J, Yoshimoto T.
Cancer Research 2004 Feb; 64(3):1152.
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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
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