ATF6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ATF6.
Immunogen
A synthetic peptide corresponding to N-terminus 17 amino acids of human ATF6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ATF6 in MDA-MB-361 cell lysate with ATF6 polyclonal antibody (Cat # PAB13180) at (A) 0.5 and (B) 1 ug/mL .Immunocytochemistry
Immunocytochemistry of ATF6 in A-20 with ATF6 polyclonal antibody (Cat # PAB13180) at 10 ug/mL . -
Gene Info — ATF6
Entrez GeneID
22926Protein Accession#
NP_031374Gene Name
ATF6
Gene Alias
ATF6A
Gene Description
activating transcription factor 6
Omim ID
605537Gene Ontology
HyperlinkGene Summary
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM
Other Designations
OTTHUMP00000025585|activating transcription factor 6 alpha
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Interactome
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Disease
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Publication Reference
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Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism.
Mak SK, Yu CM, Sun WT, He GW, Liu XC, Yang Q.
Toxicology and Applied Pharmacology 2017 Dec; 336:84.
Application:WB-Ce, Pig, Pig coronary endothelial cells.
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The unfolded protein response.
Liu CY, Kaufman RJ.
Journal of Cell Science 2003 May; 116(Pt 10):1861.
Application:WB-Tr, Human, Mammalian cells.
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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.
Haze K, Yoshida H, Yanagi H, Yura T, Mori K.
Molecular Biology of the Cell 1999 Nov; 10(11):3787.
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The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications.
Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS.
Crit Rev Eukaryot Gene Expr 1994 Jan; 4(1):1.
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Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism.
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