TSC2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TSC2.
Immunogen
A synthetic peptide corresponding to C-terminus of human TSC2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TSC2 in L1210 cell lysate with TSC2 polyclonal antibody (Cat # PAB13146) at 1 ug/mL in the (A) absence and (B) presence of blocking peptide. -
Gene Info — TSC2
Entrez GeneID
7249Protein Accession#
NP_000539Gene Name
TSC2
Gene Alias
FLJ43106, LAM, TSC4
Gene Description
tuberous sclerosis 2
Gene Ontology
HyperlinkGene Summary
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
tuberin
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Interactome
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Pathway
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Disease
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Publication Reference
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Signaling by target of rapamycin proteins in cell growth control.
Inoki K, Ouyang H, Li Y, Guan KL.
Microbiology and Molecular Biology Reviews: MMBR 2005 Mar; 69(1):79.
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Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL.
Molecular Cell 2003 Aug; 12(2):271.
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K, Li Y, Xu T, Guan KL.
Genes & Development 2003 Jul; 17(15):1829.
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Signaling by target of rapamycin proteins in cell growth control.
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