TSC1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TSC1.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human TSC1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TSC1 in C2C12 cell lysate with TSC1 polyclonal antibody (Cat # PAB13144) at (A) 2 and (B) 4 ug. -
Gene Info — TSC1
Entrez GeneID
7248Protein Accession#
AAC51674Gene Name
TSC1
Gene Alias
KIAA0243, LAM, MGC86987, TSC
Gene Description
tuberous sclerosis 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000022439|hamartin|tuberous sclerosis 1 protein|tumor suppressor
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Interactome
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Pathway
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Disease
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Publication Reference
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Signaling by target of rapamycin proteins in cell growth control.
Inoki K, Ouyang H, Li Y, Guan KL.
Microbiology and Molecular Biology Reviews: MMBR 2005 Mar; 69(1):79.
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Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL.
Molecular Cell 2003 Aug; 12(2):271.
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K, Li Y, Xu T, Guan KL.
Genes & Development 2003 Jul; 17(15):1829.
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Signaling by target of rapamycin proteins in cell growth control.
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