CASP8 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CASP8 in HT-29 cell lysate with CASP8 polyclonal antibody (Cat # PAB13141) at 1 ug/mL in (A) the presence or (B) the absence of blocking peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
Immunogen
A synthetic peptide corresponding to C-terminus of human CASP8.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CASP8 in HT-29 cell lysate with CASP8 polyclonal antibody (Cat # PAB13141) at 1 ug/mL in (A) the presence or (B) the absence of blocking peptide. -
Gene Info — CASP8
Entrez GeneID
841Protein Accession#
NP_001219Gene Name
CASP8
Gene Alias
ALPS2B, CAP4, FLICE, FLJ17672, MACH, MCH5, MGC78473
Gene Description
caspase 8, apoptosis-related cysteine peptidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
Other Designations
FADD-homologous ICE/CED-3-like protease|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|Mch5 isoform alpha|OTTHUMP00000163718|OTTHUMP00000163719|OTTHUMP00000163720|caspase 8|caspase 8, apoptosis-related cysteine protease|cysteine protease|procaspase-8
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Interactome
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Pathway
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Disease
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Publication Reference
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon F, Tschopp J.
Cell 2004 May; 117(5):561.
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Suicidal tendencies: apoptotic cell death by caspase family proteinases.
Wolf BB, Green DR.
The Journal of Biological Chemistry 1999 Jul; 274(29):20049.
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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM.
Cell 1996 Jun; 85(6):817.
Application：WB-Tr, Human, HEK 293T cells.
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
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