CASP6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP6.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human CASP6.
Host
Rabbit
Reactivity
Human
Specificity
Anti-Caspase-6 is human specific. Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CASP6 in MCF-7 cell lysate with CASP6 polyclonal antibody (Cat # PAB13138) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of CASP6 in MCF-7 with CASP6 polyclonal antibody (Cat # PAB13138) at 1 ug/mL . -
Gene Info — CASP6
Entrez GeneID
839Protein Accession#
NP_001217Gene Name
CASP6
Gene Alias
MCH2
Gene Description
caspase 6, apoptosis-related cysteine peptidase
Omim ID
601532Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
apoptotic protease MCH-2|caspase 6|caspase 6, apoptosis-related cysteine protease
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Interactome
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Pathway
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Disease
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Publication Reference
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon F, Tschopp J.
Cell 2004 May; 117(5):561.
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Suicidal tendencies: apoptotic cell death by caspase family proteinases.
Wolf BB, Green DR.
The Journal of Biological Chemistry 1999 Jul; 274(29):20049.
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Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
Fernandes-Alnemri T, Litwack G, Alnemri ES.
Cancer Research 1995 Jul; 55(13):2737.
Application:WB-Ce, WB-Re, Human, Jurkat cells, Pre-B lymphocytes, Recombinant proteins.
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
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