IRF3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRF3.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human IRF3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IRF3 in U-937 whole cell lysate with IRF3 polyclonal antibody (Cat # PAB13123) at (A) 1, (B) 2, and (C) 4 ug/mL .Immunocytochemistry
Immunocytochemistry of IRF3 in Ramos cells with IRF3 polyclonal antibody (Cat # PAB13123) at 2 ug/mL . -
Gene Info — IRF3
Entrez GeneID
3661Protein Accession#
NP_001562Gene Name
IRF3
Gene Alias
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Gene Description
interferon regulatory factor 3
Omim ID
603734Gene Ontology
HyperlinkGene Summary
IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Induction and regulation of IFNs during viral infections.
Malmgaard L.
Journal of Interferon & Cytokine Research 2004 Aug; 24(8):439.
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T.
Nature Immunology 2003 May; 4(5):491.
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Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Au WC, Moore PA, Lowther W, Juang YT, Pitha PM.
PNAS 1995 Dec; 92(25):11657.
Application:WB-Re, Recombinant protein.
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Induction and regulation of IFNs during viral infections.
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