XAF1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of XAF1 in human spleen lysate with XAF1 polyclonal antibody (Cat # PAB13116) at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL , respectively.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human spleen tissue using XAF1 polyclonal antibody (Cat # PAB13116) at 2 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XAF1.
Immunogen
A synthetic peptide corresponding to C-terminus of human XAF1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
A 32 KDa band can be detected.
Form
Liquid
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of XAF1 in human spleen lysate with XAF1 polyclonal antibody (Cat # PAB13116) at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL , respectively.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human spleen tissue using XAF1 polyclonal antibody (Cat # PAB13116) at 2 ug/mL . -
Gene Info — XAF1
Entrez GeneID
54739Protein Accession#
CAA68030Gene Name
XAF1
Gene Alias
BIRC4BP, HSXIAPAF1, XIAPAF1
Gene Description
XIAP associated factor 1
Omim ID
606717Gene Ontology
HyperlinkGene Summary
X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM
Other Designations
BIRC4 binding protein
-
Interactome
-
Publication Reference
-
Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis.
Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC.
The Journal of Biological Chemistry 2002 Aug; 277(32):28504.
Application：WB-Ce, WB-Tr, Human, A375, HeLa, WM9, WM35, WM164, WM3211 cells.
-
Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines.
Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG.
Genomics 2000 Nov; 70(1):113.
-
X-linked IAP is a direct inhibitor of cell-death proteases.
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
Natrue 1997 Jul; 388(6639):300.
-
Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com