BMF polyclonal antibody
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More Files
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Immunofluorescence
Immunofluorescence of BMF in human kidney tissue with BMF polyclonal antibody (Cat # PAB13104) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMF.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human BMF.
Host
Rabbit
Reactivity
Human
Specificity
HepG2 or 293 cell lysate can be used as a positive control and a band at approximately 25 KDa can be detected.
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunofluorescence of BMF in human kidney tissue with BMF polyclonal antibody (Cat # PAB13104) at 10 ug/mL . -
Gene Info — BMF
Entrez GeneID
90427Protein Accession#
NP_277038Gene Name
BMF
Gene Alias
FLJ00065
Gene Description
Bcl2 modifying factor
Omim ID
606266Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A.
Science 2001 Sep; 293(5536):1829.
Application：WB-Ce, Human, MCF-7 cells.
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Apoptosis. Till death us do part.
Hunt A, Evan G.
Science 2001 Sep; 293(5536):1784.
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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
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