NOD2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NOD2.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human NOD2.
Host
Rabbit
Reactivity
Human
Specificity
NOD2 has no cross-reaction with NOD1.
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NOD2 in HeLa cell lysate with NOD2 polyclonal antibody (Cat # PAB13103) at (A) 2 and (B) 4 ug/mL .Immunocytochemistry
Immunocytochemistry of NOD2 in HeLa cells with NOD2 polyclonal antibody (Cat # PAB13103) at 10 ug/mL . -
Gene Info — NOD2
Entrez GeneID
64127Protein Accession#
Q9HC29Gene Name
NOD2
Gene Alias
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Gene Description
nucleotide-binding oligomerization domain containing 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq
Other Designations
NLR family, CARD domain containing 2|NOD-like receptor C2|OTTHUMP00000164224|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-bin
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Interactome
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Disease
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Publication Reference
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G.
Nature 2001 May; 411(6837):599.
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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G, Cho JH.
Nature 2001 May; 411(6837):603.
Application:WB-Tr, Human, HEK 293T cells.
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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G.
The Journal of Biological Chemistry 1999 May; 274(21):14560.
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
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