IL21R polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of IL21R expression in human Raji cell lysate with IL21R polyclonal antibody (Cat # PAB13095) at 1 ug /mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IL21R.
Immunogen
A synthetic peptide corresponding to amino acids 20-32 of human IL21R.
Sequence
CPDLVCYTDYLQT
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IL21R expression in human Raji cell lysate with IL21R polyclonal antibody (Cat # PAB13095) at 1 ug /mL . -
Gene Info — IL21R
Entrez GeneID
50615Protein Accession#
NP_068570Gene Name
IL21R
Gene Alias
MGC10967, NILR
Gene Description
interleukin 21 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
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Interactome
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Publication Reference
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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.
Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K.
The Journal of Immunology 2001 Jul; 167(1):1.
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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D.
Nature 2000 Nov; 408(6808):57.
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Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ.
PNAS 2000 Oct; 97(21):11439.
Application：IP, IP-WB, Human, PBMCs, MT-2, YT, HUT-102B2, Raji, CEM, Molt4, K562 cells.
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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.
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