BCL2L11 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BCL2L11 in K-562 (K) and A-549 (A) whole cell lysates with BCL2L11 polyclonal antibody (Cat # PAB13076) at 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BCL2L11 in human skin cancer cells with BCL2L11 polyclonal antibody (Cat # PAB13076) at 20 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2L11.
Immunogen
A synthetic peptide corresponding to internal region of human BCL2L11.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
The sequence is identical to that of mouse and differs from that of rat by one amino acid. A 23 KDa band can be detected.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BCL2L11 in K-562 (K) and A-549 (A) whole cell lysates with BCL2L11 polyclonal antibody (Cat # PAB13076) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BCL2L11 in human skin cancer cells with BCL2L11 polyclonal antibody (Cat # PAB13076) at 20 ug/mL . -
Gene Info — BCL2L11
Entrez GeneID
10018Protein Accession#
O43521Gene Name
BCL2L11
Gene Alias
BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL
Gene Description
BCL2-like 11 (apoptosis facilitator)
Omim ID
603827Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq
Other Designations
BCL2-like 11|bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-related ovarian death agonist
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Interactome
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Disease
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Publication Reference
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BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
Hsu SY, Lin P, Hsueh AJ.
Molecular Endocrinology (Baltimore, Md.) 1998 Sep; 12(9):1432.
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Bim: a novel member of the Bcl-2 family that promotes apoptosis.
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC.
The EMBO Journal 1998 Jan; 17(2):384.
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BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
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