CRADD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CRADD.
Immunogen
A synthetic peptide corresponding to C-terminus of human CRADD.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CRADD in HeLa total cell lysate with CRADD polyclonal antibody (Cat # PAB13067) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CRADD in human kidney tissue with CRADD polyclonal antibody (Cat # PAB13067) at 10 ug/mL . -
Gene Info — CRADD
Entrez GeneID
8738Protein Accession#
AAB42217Gene Name
CRADD
Gene Alias
MGC9163, RAIDD
Gene Description
CASP2 and RIPK1 domain containing adaptor with death domain
Omim ID
603454Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq
Other Designations
RIP-associated ICH1/CED3-homologous protein with death domain|RIP-associated protein with a death domain|caspase and RIP adaptor with death domain|death adaptor molecule RAIDD|death domain containing protein CRADD
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Interactome
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Disease
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Publication Reference
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The CARD domain: a new apoptotic signalling motif.
Hofmann K, Bucher P, Tschopp J.
Trends in Biochemical Sciences 1997 May; 22(5):155.
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CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES.
Cancer Research 1997 Feb; 57(4):615.
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RAIDD is a new 'death' adaptor molecule.
Duan H, Dixit VM.
Nature 1997 Jan; 385(6611):86.
Application:WB-Tr, Human, 293 cells.
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The CARD domain: a new apoptotic signalling motif.
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