CCR3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCR3.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human CCR3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CCR3 in human spleen tissue lysates with CCR3 polyclonal antibody (Cat # PAB13064) at 1 (lane 1) and 2 ug/mL (lane 2), and 2 ug/mL in the presence of blocking peptide (lane 3).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CCR3 in human spleen tissue with CCR3 polyclonal antibody (Cat # PAB13064) at 10 ug/mL . -
Gene Info — CCR3
Entrez GeneID
1232Protein Accession#
NP_847899Gene Name
CCR3
Gene Alias
CC-CKR-3, CD193, CKR3, CMKBR3, MGC102841
Gene Description
chemokine (C-C motif) receptor 3
Omim ID
601268Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
CC chemokine receptor 3|OTTHUMP00000164718|b-chemokine receptor|eosinophil CC chemokine receptor 3|eosinophil eotaxin receptor
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Interactome
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Publication Reference
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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D.
Nature 1997 Feb; 385(6617):645.
Application:IF, Human, Brain, Primary brain culture cells.
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The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J.
Cell 1996 Jun; 85(7):1135.
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Identification of a major co-receptor for primary isolates of HIV-1.
Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR.
Nature 1996 Jun; 381(6584):661.
Application:WB-Tr, Mouse, NIH/3T3 cells.
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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
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