PARL polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PARL in NIH/3T3 cell lysate with PARL polyclonal antibody (Cat # PAB13061) at (A) 1 and (B) 2 ug/mL .
Immunocytochemistry
Immunocytochemical staining of BALB/3T3 cells with 2.5 ug/mL PARL polyclonal antibody (Cat # PAB13061).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PARL.
Immunogen
A synthetic peptide corresponding to N-terminus 15 amino acids of human PARL.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PARL in NIH/3T3 cell lysate with PARL polyclonal antibody (Cat # PAB13061) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemical staining of BALB/3T3 cells with 2.5 ug/mL PARL polyclonal antibody (Cat # PAB13061). -
Gene Info — PARL
Entrez GeneID
55486Protein Accession#
Q9H300Gene Name
PARL
Gene Alias
PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Gene Description
presenilin associated, rhomboid-like
Omim ID
607858Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
mitochondrial intramembrane-cleaving protease PARL|rhomboid 7 homolog 1
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Interactome
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Disease
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Publication Reference
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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN.
Nature 2008 Feb; 452(7183):98.
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Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B.
Cell 2006 Jul; 126(1):163.
Application：WB, Mouse, MEFs, Mouse liver mitochondria.
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PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2.
Pellegrini L, Passer BJ, Canelles M, Lefterov I, Ganjei JK, Fowlkes BJ, Koonin EV, D'Adamio L.
Journal of Alzheimer's Disease 2001 Apr; 3(2):181.
Application：IF, WB-Tr, Human, Monkey, HEK 293, COS-7 cells.
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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
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