ASAH2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ASAH2.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human ASAH2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ASAH2 in 293 cell lysate with ASAH2 polyclonal antibody (Cat # PAB13057) at (A) 1 and (B) 2 ug/mL . -
Gene Info — ASAH2
Entrez GeneID
56624Protein Accession#
NP_063946Gene Name
ASAH2
Gene Alias
HNAC1, MGC129777, NCDase
Gene Description
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Omim ID
611202Gene Ontology
HyperlinkGene Summary
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM
Other Designations
N-acylsphingosine amidohydrolase 2|mitochondrial ceramidase|neutral ceramidase|neutral/alkaline ceramidase|non-lysosomal ceramidase
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Pathway
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Disease
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Publication Reference
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA.
The Journal of Biological Chemistry 2005 Jul; 280(30):27879.
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O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein.
Tani M, Iida H, Ito M.
The Journal of Biological Chemistry 2003 Mar; 278(12):10523.
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Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract.
Nilsson A, Duan RD.
Chemistry and Physics of Lipids 1999 Nov; 102(1-2):97.
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
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