CPEB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CPEB1 in rat brain tissue lysate with CPEB1 polyclonal antibody (Cat # PAB13049) at (A) 1 and (B) 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CPEB1.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human CPEB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CPEB1 in rat brain tissue lysate with CPEB1 polyclonal antibody (Cat # PAB13049) at (A) 1 and (B) 2 ug/mL . -
Gene Info — CPEB1
Entrez GeneID
64506Protein Accession#
Q9BZB8Gene Name
CPEB1
Gene Alias
CEBP, CPE-BP1, CPEB, FLJ13203, MGC34136, MGC60106
Gene Description
cytoplasmic polyadenylation element binding protein 1
Omim ID
607342Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CPE-binding protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.
Hagele S, Kuhn U, Boning M, Katschinski DM.
The Biochemical Journal 2009 Jan; 417(1):235.
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CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes.
Jones KJ, Korb E, Kundel MA, Kochanek AR, Kabraji S, McEvoy M, Shin CY, Wells DG.
Glia 2008 Oct; 56(13):1401.
Application：ICC, IHC, WB-Ce, Rat, Rat astrocytes.
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CPEB: a life in translation.
Richter JD.
Trends in Biochemical Sciences 2007 Jun; 32(6):279.
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Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.
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