WNT10B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of WNT10B.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human WNT10B.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of WNT10B in human skeletal muscle tissue lysate with WNT10B polyclonal antibody (Cat # PAB13039) at (A) 2 and (B) 4 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of WNT10B in human skeletal muscle with WNT10B polyclonal antibody (Cat # PAB13039) at 2.5 ug/mL . -
Gene Info — WNT10B
Entrez GeneID
7480Protein Accession#
NP_003385Gene Name
WNT10B
Gene Alias
SHFM6, WNT-12
Gene Description
wingless-type MMTV integration site family, member 10B
Omim ID
601906Gene Ontology
HyperlinkGene Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq
Other Designations
WNT-10B protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells.
Bennett CN, Hodge CL, MacDougald OA, Schwartz J.
Biochemical and Biophysical Research Communications 2003 Feb; 302(1):12.
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A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas.
Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S.
Oncogene 1997 Mar; 14(10):1249.
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Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.
Lee FS, Lane TF, Kuo A, Shackleford GM, Leder P.
PNAS 1995 Mar; 92(6):2268.
Application:WB-Ti, Mouse, Mouse mammary epithelium.
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Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells.
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