GPAM polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GPAM.
Immunogen
A synthetic peptide corresponding to C-terminu 15 amino acids of human GPAM.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of GPAM in rat brain tissue lysate with GPAM polyclonal antibody (Cat # PAB13037) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of GPAM in rat brain with GPAM polyclonal antibody (Cat # PAB13037) at 2.5 ug/mL . -
Gene Info — GPAM
Entrez GeneID
57678Protein Accession#
NP_065969Gene Name
GPAM
Gene Alias
GPAT1, KIAA1560, MGC26846, RP11-426E5.2
Gene Description
glycerol-3-phosphate acyltransferase, mitochondrial
Omim ID
602395Gene Ontology
HyperlinkGene Summary
Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria.[supplied by OMIM
Other Designations
glycerol 3-phosphate acyltransferase, mitochondrial|mitochondrial glycerol 3-phosphate acyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition.
Lewin TM, de Jong H, Schwerbrock NJ, Hammond LE, Watkins SM, Combs TP, Coleman RA.
Biochimica et Biophysica Acta 2008 Jun; 1781(6-7):352.
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SREBP transcription factors: master regulators of lipid homeostasis.
Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F.
Biochimica et Biophysica Acta 2004 Nov; 86(11):839.
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Enzymes of triacylglycerol synthesis and their regulation.
Coleman RA, Lee DP.
Progress in Lipid Research 2004 Mar; 43(2):134.
Application:WB, Human, Mammalian cells.
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Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition.
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