VGF polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of VGF.
Immunogen
A synthetic peptide corresponding to C-terminus 17 amino acids of human VGF.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of VGF in human brain tissue lysate with VGF polyclonal antibody (Cat # PAB13036) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of VGF in human brain with VGF polyclonal antibody (Cat # PAB13036) at 5 ug/mL . -
Gene Info — VGF
Entrez GeneID
7425Protein Accession#
NP_003369Gene Name
VGF
Gene Alias
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Gene Description
VGF nerve growth factor inducible
Omim ID
602186Gene Ontology
HyperlinkGene Summary
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq
Other Designations
neuro-endocrine specific protein VGF|neurosecretory protein VGF
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Interactome
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Disease
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Publication Reference
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Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.
Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR.
Neuron 1999 Jul; 23(3):537.
Application:WB-Ti, Mouse, Mouse forebrain.
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A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway.
Possenti R, Eldridge JD, Paterson BM, Grasso A, Levi A.
The EMBO Journal 1989 Aug; 8(8):2217.
Application:IF, IP, WB-Ce, WB-Re, Rat, PC-12 cells, Recombinant proteins.
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Molecular cloning of a gene sequence regulated by nerve growth factor.
Levi A, Eldridge JD, Paterson BM.
Science 1985 Jul; 229(4711):393.
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Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.
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