NPTX2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of NPTX2 in mouse brain tissue lysate with NPTX2 polyclonal antibody (Cat # PAB13033) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NPTX2 in human brain with NPTX2 polyclonal antibody (Cat # PAB13033) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NPTX2.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human NPTX2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of NPTX2 in mouse brain tissue lysate with NPTX2 polyclonal antibody (Cat # PAB13033) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of NPTX2 in human brain with NPTX2 polyclonal antibody (Cat # PAB13033) at 5 ug/mL . -
Gene Info — NPTX2
Entrez GeneID
4885Protein Accession#
NP_002514Gene Name
NPTX2
Gene Alias
NARP, NP-II, NP2
Gene Description
neuronal pentraxin II
Omim ID
600750Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq
Other Designations
apexin|neuronal activity-regulated pentaxin|pentraxin II
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Interactome
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Disease
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Publication Reference
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Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies.
Moran LB, Hickey L, Michael GJ, Derkacs M, Christian LM, Kalaitzakis ME, Pearce RK, Graeber MB.
Acta Neuropathologica 2008 Apr; 115(4):471.
Application：IHC-P, WB-Ti, Human, Brain from patients with Parkinson's disease.
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Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity.
Tsui CC, Copeland NG, Gilbert DJ, Jenkins NA, Barnes C, Worley PF.
The Journal of Neuroscience 1996 Apr; 16(8):2463.
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Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization.
Hsu YC, Perin MS.
Genomics 1995 Jul; 28(2):220.
Application：WB-Ce, WB-Ti, Human, Mammalian cells, Tissues.
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Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies.
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