ELOVL6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ELOVL6.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human ELOVL6.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ELOVL6 in human brain tissue lysate with ELOVL6 polyclonal antibody (Cat # PAB13032) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of ELOVL6 in human brain with ELOVL6 polyclonal antibody (Cat # PAB13032) at 5 ug/mL . -
Gene Info — ELOVL6
Entrez GeneID
79071Protein Accession#
NP_076995Gene Name
ELOVL6
Gene Alias
FACE, FAE, FLJ23378, LCE, MGC5487
Gene Description
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
Omim ID
611546Gene Ontology
HyperlinkGene Summary
Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM
Other Designations
OTTHUMP00000163370|elongation of very long chain fatty acids-like 6|long-chain fatty-acyl elongase
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Interactome
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Publication Reference
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Protective Effects of White Button Mushroom (Agaricus bisporus) against Hepatic Steatosis in Ovariectomized Mice as a Model of Postmenopausal Women.
Kanaya N, Kubo M, Liu Z, Chu P, Wang C, Chen YC.
PLoS One 2011 Oct; 6(10):e26654.
Application:WB-Ce, Human, HepG2 cells.
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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N.
Nature Medicine 2007 Oct; 13(10):1193.
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Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S, Yamada N.
Journal of Lipid Research 2002 Jun; 43(6):911.
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Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins.
Moon YA, Shah NA, Mohapatra S, Warrington JA, Horton JD.
The Journal of Biological Chemistry 2001 Nov; 276(48):45358.
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Protective Effects of White Button Mushroom (Agaricus bisporus) against Hepatic Steatosis in Ovariectomized Mice as a Model of Postmenopausal Women.
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