GRIK3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIK3.
Immunogen
A synthetic peptide corresponding to N-terminus 13 amino acids of human GRIK3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of GRIK3 in human brain tissue lysate with GRIK3 polyclonal antibody (Cat # PAB13015) at (A) 1 and (B) 2 ug/mL . -
Gene Info — GRIK3
Entrez GeneID
2899Protein Accession#
CAI19119Gene Name
GRIK3
Gene Alias
EAA5, GLR7, GLUR7, GluR7a
Gene Description
glutamate receptor, ionotropic, kainate 3
Omim ID
138243Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq
Other Designations
OTTHUMP00000004360|dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))|excitatory amino acid receptor 5|glutamate receptor 7
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Publication Reference
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GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
Pinheiro PS, Perrais D, Coussen F, Barhanin J, Bettler B, Mann JR, Malva JO, Heinemann SF, Mulle C.
PNAS 2007 Jul; 104(29):12181.
Application:WB-Ti, Mouse, Mouse hippocampal synaptosomal membranes.
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Kainate receptors.
Pinheiro P, Mulle C.
Cell and Tissue Research 2006 Jul; 326(2):457.
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Chromosomal localization of gene for human glutamate receptor subunit-7.
Puranam RS, Eubanks JH, Heinemann SF, McNamara JO.
Somatic Cell and Molecular Genetics 1993 Nov; 19(6):581.
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GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
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