STEAP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of STEAP2 in human prostate tissue lysate with STEAP2 polyclonal antibody (Cat # PAB13007) at 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STEAP2 in human colon tissue with STEAP2 polyclonal antibody (Cat # PAB13007) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STEAP2.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human STEAP2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of STEAP2 in human prostate tissue lysate with STEAP2 polyclonal antibody (Cat # PAB13007) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STEAP2 in human colon tissue with STEAP2 polyclonal antibody (Cat # PAB13007) at 2.5 ug/mL . -
Gene Info — STEAP2
Entrez GeneID
261729Protein Accession#
Q8NFT2Gene Name
STEAP2
Gene Alias
IPCA1, PCANAP1, PUMPCn, STAMP1, STMP
Gene Description
six transmembrane epithelial antigen of the prostate 2
Omim ID
605094Gene Ontology
HyperlinkGene Summary
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000067572|OTTHUMP00000067575|SixTransMembrane Protein of Prostate 1|prostate cancer associated protein 1|protein upregulated in metastatic prostate cancer|six transmembrane epithelial antigen of prostate 2
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Interactome
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Disease
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Publication Reference
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The Steap proteins are metalloreductases.
Ohgami RS, Campagna DR, McDonald A, Fleming MD.
Blood 2006 Aug; 108(4):1388.
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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.
Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD.
Nature Genetics 2005 Oct; 37(11):1264.
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Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.
Porkka KP, Helenius MA, Visakorpi T.
Laboratory Investigation 2002 Nov; 82(11):1573.
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The Steap proteins are metalloreductases.
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