PAFAH1B1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAFAH1B1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human PAFAH1B1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PAFAH1B1 in HeLa cell lysate with PAFAH1B1 polyclonal antibody (Cat # PAB13006) at (A) 0.5 and (B) 1 ug/mL . -
Gene Info — PAFAH1B1
Entrez GeneID
5048Protein Accession#
P43034Gene Name
PAFAH1B1
Gene Alias
LIS1, LIS2, MDCR, MDS, PAFAH
Gene Description
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
Gene Ontology
HyperlinkGene Summary
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq
Other Designations
Platelet-activating factor acetylhydrolase, isoform 1B, alpha subunit|lissencephaly 1 protein|platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Neuronal migration in developmental disorders.
McManus MF, Golden JA.
Journal of Child Neurology 2005 Apr; 20(4):280.
Application:IHC, WB, Human, Mouse, Brains.
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Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected].
Hattori M, Adachi H, Tsujimoto M, Arai H, Inoue K.
Nature 1994 Jul; 370(6486):216.
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Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.
Reiner O, Carrozzo R, Shen Y, Wehnert M, Faustinella F, Dobyns WB, Caskey CT, Ledbetter DH.
Nature 1993 Aug; 364(6439):717.
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Neuronal migration in developmental disorders.
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