MICA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MICA.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human MICA.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MICA in A-20 cell lysate with MICA polyclonal antibody (Cat # PAB13003) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of MICA in human colon tissue with MICA polyclonal antibody (Cat # PAB13003) at 10 ug/mL . -
Gene Info — MICA
Entrez GeneID
4276Protein Accession#
NP_000238Gene Name
MICA
Gene Alias
FLJ60820, MGC111087, PERB11.1
Gene Description
MHC class I polypeptide-related sequence A
Omim ID
600169Gene Ontology
HyperlinkGene Summary
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. [provided by RefSeq
Other Designations
HLA class I antigen|MHC class I chain-related gene A protein|MHC class I chain-related protein A|OTTHUMP00000029088|OTTHUMP00000035033|OTTHUMP00000035034|Stress inducible class I homolog
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Pathway
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Disease
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Publication Reference
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NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.
Maccalli C, Pende D, Castelli C, Mingari MC, Robbins PF, Parmiani G.
European Journal of Immunology 2003 Jul; 33(7):2033.
Application:Flow Cyt, Func, Human, T cells.
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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T.
Science 1999 Jul; 285(5428):727.
Application:Flow Cyt, Func, IP, Human, Mouse, Ba/F3, Jurkat cells, Nature killer cells.
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A second lineage of mammalian major histocompatibility complex class I genes.
Bahram S, Bresnahan M, Geraghty DE, Spies T.
PNAS 1994 Jul; 91(14):6259.
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NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.
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