TBC1D1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TBC1D1.
Immunogen
A synthetic peptide corresponding to C-terminus 22 amino acids of human TBC1D1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TBC1D1 in Daudi cell lysate with TBC1D1 polyclonal antibody (Cat # PAB12998) at (A) 1, (B) 2 and (C) 4 ug/mL . -
Gene Info — TBC1D1
Entrez GeneID
23216Protein Accession#
NP_055988Gene Name
TBC1D1
Gene Alias
KIAA1108, TBC, TBC1
Gene Description
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Omim ID
609850Gene Ontology
HyperlinkGene Summary
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.
Roach WG, Chavez JA, Miinea CP, Lienhard GE.
The Biochemical Journal 2007 Apr; 403(2):353.
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Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways.
Koumanov F, Holman GD.
The Biochemical Journal 2007 Apr; 403(2):e9.
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TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.
Stone S, Abkevich V, Russell DL, Riley R, Timms K, Tran T, Trem D, Frank D, Jammulapati S, Neff CD, Iliev D, Gress R, He G, Frech GC, Adams TD, Skolnick MH, Lanchbury JS, Gutin A, Hunt SC, Shattuck D.
Human Molecular Genetics 2006 Sep; 15(18):2709.
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Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.
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