HAP1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 polyclonal antibody (Cat # PAB12994) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of HAP1 in human brain tissue with HAP1 polyclonal antibody (Cat # PAB12994) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HAP1.
Immunogen
A synthetic peptide corresponding to internal region 19 amino acids of human HAP1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 polyclonal antibody (Cat # PAB12994) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of HAP1 in human brain tissue with HAP1 polyclonal antibody (Cat # PAB12994) at 2.5 ug/mL . -
Gene Info — HAP1
Entrez GeneID
9001Protein Accession#
CAC09418Gene Name
HAP1
Gene Alias
HAP2, HIP5, HLP, hHLP1
Gene Description
huntingtin-associated protein 1
Omim ID
600947Gene Ontology
HyperlinkGene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000164747|huntingtin-associated protein 2|neuroan 1
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Interactome
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Disease
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Publication Reference
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Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
Borrell-Pages M, Zala D, Humbert S, Saudou F.
Cellular and Molecular Life Sciences 2006 Nov; 63(22):2642.
Application：WB, Human, Human mammalian cells, Tumors.
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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Gauthier LR, Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H, Cordelieres FP, De Mey J, MacDonald ME, Lessmann V, Humbert S, Saudou F.
Cell 2004 Jul; 118(1):127.
Application：IF, WB, Human, NG108-15 cells.
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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA.
Human Molecular Genetics 1997 Dec; 6(13):2205.
Application：IF, WB-Ti, Rat, Brains, PC12 cells.
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Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
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