PSEN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
Immunogen
A synthetic peptide corresponding to C-terminus 23 amino acids of human PSEN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody has no cross-reactivity to presenilin2.
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PSEN1 in human brain lysate with PSEN1 polyclonal antibody (Cat # PAB12993) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PSEN1 in human brain tissue with PSEN1 polyclonal antibody (Cat # PAB12993) at 2.5 ug/mL . -
Gene Info — PSEN1
Entrez GeneID
5663Protein Accession#
NP_000012Gene Name
PSEN1
Gene Alias
AD3, FAD, PS1, S182
Gene Description
presenilin 1
Gene Ontology
HyperlinkGene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.
Journal of Neuroscience Research 2004 Aug; 77(3):309.
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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ.
Trends in Cell Biology 1998 Nov; 8(11):447.
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al..
Nature 1995 Jun; 375(6534):754.
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
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