PRSS12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PRSS12 in SK-N-SH cell lysate with PRSS12 polyclonal antibody (Cat # PAB12990) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PRSS12 in human brain tissue with PRSS12 polyclonal antibody (Cat # PAB12990) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRSS12.
Immunogen
A synthetic peptide corresponding to N-terminus 23 amino acids of human PRSS12.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PRSS12 in SK-N-SH cell lysate with PRSS12 polyclonal antibody (Cat # PAB12990) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PRSS12 in human brain tissue with PRSS12 polyclonal antibody (Cat # PAB12990) at 2.5 ug/mL . -
Gene Info — PRSS12
Entrez GeneID
8492Protein Accession#
CAA04816Gene Name
PRSS12
Gene Alias
BSSP-3, BSSP3, MGC12722, MRT1
Gene Description
protease, serine, 12 (neurotrypsin, motopsin)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. [provided by RefSeq
Other Designations
brain-specific serine protease 3|leydin|motopsin|neurotrypsin
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Interactome
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Disease
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Publication Reference
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Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation.
Mitsui S, Yamaguchi N, Osako Y, Yuri K.
Brain Research 2007 Mar; 1136(1):1.
Application：IF, IHC, WB-Tr, WB-Re, Human, Mouse, HEK 293 cells, Mouse central nervous system, Recombinant protein.
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Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.
Molinari F, Rio M, Meskenaite V, Encha-Razavi F, Auge J, Bacq D, Briault S, Vekemans M, Munnich A, Attie-Bitach T, Sonderegger P, Colleaux L.
Science 2002 Nov; 298(5599):1779.
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Neurotrypsin, a novel multidomain serine protease expressed in the nervous system.
Gschwend TP, Krueger SR, Kozlov SV, Wolfer DP, Sonderegger P.
Molecular and Cellular Neurosciences 1997 Jan; 9(3):207.
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Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation.
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