CD82 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CD82.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human CD82.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CD82 in A-549 cell lysate with CD82 polyclonal antibody (Cat # PAB12987) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CD82 in human colon tissue with CD82 polyclonal antibody (Cat # PAB12987) at 2.5 ug/mL . -
Gene Info — CD82
Entrez GeneID
3732Protein Accession#
NP_002222Gene Name
CD82
Gene Alias
4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27
Gene Description
CD82 molecule
Gene Ontology
HyperlinkGene Summary
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
C33 antigen|CD82 antigen|R2 leukocyte antigen|inducible membrane protein R2|kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))|suppression of tumorigenicity 6|suppress
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Interactome
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Pathway
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Publication Reference
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KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.
Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC.
Science 1995 May; 268(5212):884.
Application:WB-Ce, WB-Ti, Human, DU 145, LNCaP, PC-3, Prostate tissues, TSU- Prl cells.
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A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies.
Gil ML, Vita N, Lebel-Binay S, Miloux B, Chalon P, Kaghad M, Marchiol-Fournigault C, Conjeaud H, Caput D, Ferrara P, et al.
The Journal of Immunology 1992 May; 148(9):2826.
Application:IF, Human, U937 cells.
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A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23.
Gaugitsch HW, Hofer E, Huber NE, Schnabl E, Baumruker T.
European Journal of Immunology 1991 Feb; 21(2):377.
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KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.
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