SCO2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SCO2.
Immunogen
A synthetic peptide corresponding to C-terminus 19 amino acids of human SCO2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SCO2 in human liver tissue lysate with SCO2 polyclonal antibody (Cat # PAB12984) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of SCO2 in human liver tissue with SCO2 polyclonal antibody (Cat # PAB12984) at 2.5 ug/mL . -
Gene Info — SCO2
Entrez GeneID
9997Protein Accession#
O43819Gene Name
SCO2
Gene Alias
MGC125823, MGC125825, SCO1L
Gene Description
SCO cytochrome oxidase deficient homolog 2 (yeast)
Gene Ontology
HyperlinkGene Summary
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog of the yeast SCO2 gene. [provided by RefSeq
Other Designations
OTTHUMP00000196773|SCO (cytochrome oxidase deficient, yeast) homolog 2|cytochrome oxidase deficient homolog 2
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Interactome
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Disease
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Publication Reference
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Untersuchungen zur Wirkungsweise des Radioprotektors O-Phospho-L-Tyrosin auf die Zellreparatur und den Metabolismus der Zelle.
Angela Paasch.
Thesis for: doctoral 2015 Jan; 1.
Application:WB-Ce, WB-Tr, Human, A-549, HSF7 cells.
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p53 regulates mitochondrial respiration.
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM.
Science 2006 Jun; 312(5780):1650.
Application:WB, Human, DLD-1, HCT-116 cells, Mouse liver.
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Human Sco1 and Sco2 function as copper-binding proteins.
Horng YC, Leary SC, Cobine PA, Young FB, George GN, Shoubridge EA, Winge DR.
The Journal of Biological Chemistry 2005 Oct; 280(40):34113.
Application:WB, Human, Human skin fibroblasts.
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SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae.
Glerum DM, Shtanko A, Tzagoloff A.
The Journal of Biological Chemistry 1996 Aug; 271(34):20531.
Application:WB-Re, WB-Tr, Yeast, Recombinant proteins, Yeast cells.
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Untersuchungen zur Wirkungsweise des Radioprotektors O-Phospho-L-Tyrosin auf die Zellreparatur und den Metabolismus der Zelle.
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