EMD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EMD.
Immunogen
A synthetic peptide corresponding to N-terminus 19 amino acids of human EMD.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of EMD in human skeletal muscle tissue lysate with EMD polyclonal antibody (Cat # PAB12982) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of EMD in human skeletal muscle tissue with EMD polyclonal antibody (Cat # PAB12982) at 2.5 ug/mL . -
Gene Info — EMD
Entrez GeneID
2010Protein Accession#
NP_000108Gene Name
EMD
Gene Alias
EDMD, LEMD5, STA
Gene Description
emerin
Gene Ontology
HyperlinkGene Summary
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq
Other Designations
LEM domain containing 5|OTTHUMP00000031938|OTTHUMP00000061687
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Interactome
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Pathway
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Disease
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Publication Reference
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Lamins: building blocks or regulators of gene expression?
Hutchison CJ.
Nature Reviews. Molecular Cell Biology 2002 Nov; 3(11):848.
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Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.
Cai M, Huang Y, Ghirlando R, Wilson KL, Craigie R, Clore GM.
EMBO J 2001 Aug; 20(16):4399.
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The barrier-to-autointegration protein is a host factor for HIV type 1 integration.
Chen H, Engelman A.
PNAS 1998 Dec; 95(26):15270.
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Lamins: building blocks or regulators of gene expression?
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