FAF1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FAF1.
Immunogen
A synthetic peptide corresponding to C-terminus 19 amino acids of human FAF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of FAF1 in Jurkat cell lysate with FAF1 polyclonal antibody (Cat # PAB12980) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of FAF1 in rat spleen tissue with FAF1 polyclonal antibody (Cat # PAB12980) at 2.5 ug/mL . -
Gene Info — FAF1
Entrez GeneID
11124Protein Accession#
NP_008982Gene Name
FAF1
Gene Alias
CGI-03, FLJ37524, HFAF1s, UBXD12, UBXN3A, hFAF1
Gene Description
Fas (TNFRSF6) associated factor 1
Omim ID
604460Gene Ontology
HyperlinkGene Summary
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq
Other Designations
FAS-associated factor 1|TNFRSF6-associated factor 1|UBX domain protein 3A
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Interactome
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Disease
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Publication Reference
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Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.
Kinoshita T, Kondoh C, Hasegawa M, Imamura R, Suda T.
International Immunology 2006 Dec; 18(12):1701.
Application:WB, Human, HEK 293T, THP-1 cells.
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Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB.
Park MY, Jang HD, Lee SY, Lee KJ, Kim E.
The Journal of Biological Chemistry 2004 Jan; 279(4):2544.
Application:WB-Tr, IP-WB, Human, Mouse, 293, NIH3T3 cells.
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A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.
Chu K, Niu X, Williams LT.
PNAS 1995 Dec; 92(25):11894.
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Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.
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