STK11 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of STK11 in PC-3 cell lysate with STK11 polyclonal antibody (Cat # PAB12979) at 1 ug/mL in the (A) absence or (B) presence of blocking peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK11.
Immunogen
A synthetic peptide corresponding to C-terminus 15 amino acids of human STK11.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of STK11 in PC-3 cell lysate with STK11 polyclonal antibody (Cat # PAB12979) at 1 ug/mL in the (A) absence or (B) presence of blocking peptide. -
Gene Info — STK11
Entrez GeneID
6794Protein Accession#
AAH19334Gene Name
STK11
Gene Alias
LKB1, PJS
Gene Description
serine/threonine kinase 11
Gene Ontology
HyperlinkGene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
polarization-related protein LKB1|serine/threonine protein kinase 11
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Interactome
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Pathway
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Disease
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Publication Reference
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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR.
The EMBO Journal 2003 Oct; 22(19):5102.
Application：WB, Human, HeLa cells.
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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG.
Journal of Biology 2003 Sep; 2(4):28.
Application：IP, WB-Tr, WB-Ti, Human, Rat, HeLa, HEK 293T cells, MEFs, Rat livers.
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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA.
Nature 1998 Jan; 391(6663):184.
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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
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