A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA.Nature. 1998 Jan 8;391(6663):184-7.
Western Blot (Cell lysate)
Western blot analysis of STK11 in PC-3 cell lysate with STK11 polyclonal antibody (Cat # PAB12979) at 1 ug/mL in the (A) absence or (B) presence of blocking peptide.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
polarization-related protein LKB1,serine/threonine protein kinase 11