PDCD4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PDCD4.
Immunogen
A synthetic peptide corresponding to C-terminus 19 amino acids of human PDCD4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PDCD4 in A-20 cell lysate with PDCD4 polyclonal antibody (Cat # PAB12978) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PDCD4 in mouse brain tissue with PDCD4 polyclonal antibody (Cat # PAB12978) at 2.5 ug/mL . -
Gene Info — PDCD4
Entrez GeneID
27250Protein Accession#
NP_663314Gene Name
PDCD4
Gene Alias
H731, MGC33046, MGC33047
Gene Description
programmed cell death 4 (neoplastic transformation inhibitor)
Omim ID
608610Gene Ontology
HyperlinkGene Summary
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020483|nuclear antigen H731|programmed cell death 4
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Interactome
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Disease
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Publication Reference
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Overview of cell death signaling pathways.
Jin Z, El-Deiry WS.
Cancer Biol Ther 2005 Feb; 4(2):139.
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Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Goke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B.
American Journal of Physiology. Cell Physiology 2004 Dec; 287(6):C1541.
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Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T.
Gene 1995 Dec; 166(2):297.
Application:WB-Ce, Mouse, Mouse lymphoid cell lines.
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Overview of cell death signaling pathways.
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