SUMO1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SUMO1.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human SUMO1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SUMO1 in HL-60 cell lysate with SUMO1 polyclonal antibody (Cat # PAB12977) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunohistochemistry
Immunocytochemistry
Immunocytochemistry of SUMO1 in HL-60 cells with SUMO1 polyclonal antibody (Cat # PAB12977) at 5 ug/mL . -
Gene Info — SUMO1
Entrez GeneID
7341Protein Accession#
AAH66306Gene Name
SUMO1
Gene Alias
DAP-1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, SUMO-1, UBL1
Gene Description
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
Omim ID
601912Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq
Other Designations
GAP modifying protein 1|SMT3 suppressor of mif two 3 homolog 1|sentrin|ubiquitin-like 1 (sentrin)
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Interactome
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Disease
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Publication Reference
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Something about SUMO inhibits transcription.
Gill G.
Current Opinion in Genetics & Development 2005 Oct; 15(5):536.
Application:WB, Human, Human mammalian cells.
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SUMO protein modification.
Dohmen RJ.
Biochimica et Biophysica Acta 2004 Nov; 1695(1-3):113.
Application:WB, Human, Mammalian cells.
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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
Desterro JM, Rodriguez MS, Hay RT.
Molecular Cell 1998 Aug; 2(2):233.
Application:WB-Ce, Human, Monkey, HeLa, Jurkat, COS-7, 293 cells.
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Something about SUMO inhibits transcription.
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