TNFSF11 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFSF11.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human TNFSF11.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TNFSF11 in rat liver tissue lysate with TNFSF11 polyclonal antibody (Cat # PAB12974) at (A) 0.25 and (B) 0.5 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TNFSF11 in human liver tissue with TNFSF11 polyclonal antibody (Cat # PAB12974) at 5 ug/mL . -
Gene Info — TNFSF11
Entrez GeneID
8600Protein Accession#
NP_003692Gene Name
TNFSF11
Gene Alias
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Gene Description
tumor necrosis factor (ligand) superfamily, member 11
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
Other Designations
OTTHUMP00000178585|TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|tumor necrosis factor ligand superfamily, member 11
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy.
Shi Hao Lee, Yeannie H Y Yap, Chew Leng Lim, Amanda Rui En Woo, Valerie C L Lin.
Scientific Reports 2022 Jul; 12(1):12286.
Application:WB-Ce, Mouse, Mouse mammary glands.
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Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism.
Bharti AC, Takada Y, Shishodia S, Aggarwal BB.
The Journal of Biological Chemistry 2004 Feb; 279(7):6065.
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Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines.
Weitzmann MN, Cenci S, Rifas L, Brown C, Pacifici R.
Blood 2000 Sep; 96(5):1873.
Application:IP, Human, PBSCs.
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM.
Nature 1999 Jan; 397(6717):315.
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Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy.
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