DDX58 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of DDX58 in C2C12 cell lysate with DDX58 polyclonal antibody (Cat # PAB12973) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of DDX58 in human heart tissue with DDX58 polyclonal antibody (Cat # PAB12973) at 5 ug/mL .
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Specification
Product Description
Rabbit Polyclonal antibody raised against recombinant DDX58.
Immunogen
Recombinant GST fusion protein corresponding to human DDX58.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DDX58 in C2C12 cell lysate with DDX58 polyclonal antibody (Cat # PAB12973) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of DDX58 in human heart tissue with DDX58 polyclonal antibody (Cat # PAB12973) at 5 ug/mL . -
Gene Info — DDX58
Entrez GeneID
23586Protein Accession#
O95786Gene Name
DDX58
Gene Alias
DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG-I
Gene Description
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Omim ID
609631Gene Ontology
HyperlinkGene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq
Other Designations
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I|OTTHUMP00000021185|OTTHUMP00000045225|RNA helicase RIG-I|retinoic acid-inducible gene I
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Interactome
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Disease
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Publication Reference
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Pathogen recognition and innate immunity.
Akira S, Uematsu S, Takeuchi O.
Cell 2006 Feb; 124(4):783.
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Triggering the interferon antiviral response through an IKK-related pathway.
Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J.
Science 2003 May; 300(5622):1148.
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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA.
Nature 2001 Oct; 413(6857):732.
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Pathogen recognition and innate immunity.
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