EDA2R polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of EDA2R in 293 cell lysate with EDA2R polyclonal antibody (Cat # PAB12963) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of EDA2R in human skin tissue with EDA2R polyclonal antibody (Cat # PAB12963) at 10 ug/mL .
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Specification
Product Description
Rabbit Polyclonal antibody raised against recombinant EDA2R.
Immunogen
Recombinant protein corresponding to human EDA2R.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of EDA2R in 293 cell lysate with EDA2R polyclonal antibody (Cat # PAB12963) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of EDA2R in human skin tissue with EDA2R polyclonal antibody (Cat # PAB12963) at 10 ug/mL . -
Gene Info — EDA2R
Entrez GeneID
60401Protein Accession#
AAQ89953Gene Name
EDA2R
Gene Alias
EDA-A2R, EDAA2R, TNFRSF27, XEDAR
Gene Description
ectodysplasin A2 receptor
Omim ID
300276Gene Ontology
HyperlinkGene Summary
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support. [provided by RefSeq
Other Designations
EDA-A2 receptor|OTTHUMP00000023448|X-linked ectodysplasin receptor|X-linked ectodysplasin-A2 receptor|tumor necrosis factor receptor superfamily member XEDAR
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Interactome
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Pathway
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Disease
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Publication Reference
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Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
Sinha SK, Chaudhary PM.
The Journal of Biological Chemistry 2004 Oct; 279(40):41873.
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Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
Sinha SK, Zachariah S, Quiñones HI, Shindo M, Chaudhary PM.
The Journal of Biological Chemistry 2002 Nov; 277(47):44953.
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Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.
Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM.
Science 2000 Oct; 290(5491):523.
Application：IF, Human, MCF-7 cells.
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Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
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