BIK polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BIK in Jurkat cell lysate with BIK polyclonal antibody (Cat # PAB12962) at (A) 1 and (B) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of BIK in Jurkat cells with BIK polyclonal antibody (Cat # PAB12962) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIK.
Immunogen
A synthetic peptide corresponding to N-terminus 15 amino acids of human BIK.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BIK in Jurkat cell lysate with BIK polyclonal antibody (Cat # PAB12962) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of BIK in Jurkat cells with BIK polyclonal antibody (Cat # PAB12962) at 1 ug/mL . -
Gene Info — BIK
Entrez GeneID
638Protein Accession#
CAG30276Gene Name
BIK
Gene Alias
BIP1, BP4, NBK
Gene Description
BCL2-interacting killer (apoptosis-inducing)
Omim ID
603392Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. [provided by RefSeq
Other Designations
BCL2-interacting killer|OTTHUMP00000028974|apoptosis-inducing NBK
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Interactome
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Disease
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Publication Reference
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BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria.
Germain M, Mathai JP, Shore GC.
The Journal of Biological Chemistry 2002 May; 277(20):18053.
Application：WB-Tr, Human, H1299 cells.
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Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.
Cell Death and Differentiation 2000 Jan; 7(1):2.
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BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria.
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