TNFSF12 polyclonal antibody
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Specification
Product Description
Rabbit Polyclonal antibody raised against recombinant TNFSF12.
Immunogen
Recombinant protein corresponding to human TNFSF12.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of (A) 5 ng, (B) 25 ng and (C) 50 ng of recombinant TNFSF12 with TNFSF12 polyclonal antibody (Cat # PAB12960) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of TNFSF12 in human brain tissue with TNFSF12 polyclonal antibody (Cat # PAB12960) at 10 ug/mL . -
Gene Info — TNFSF12
Entrez GeneID
8742Protein Accession#
NP_003800Gene Name
TNFSF12
Gene Alias
APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Gene Description
tumor necrosis factor (ligand) superfamily, member 12
Omim ID
602695Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
Other Designations
APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis
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Interactome
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Pathway
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Disease
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Publication Reference
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The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.
Kaplan MJ, Lewis EE, Shelden EA, Somers E, Pavlic R, McCune WJ, Richardson BC.
The Journal of Immunology 2002 Nov; 169(10):6020.
Application:Flow Cyt, Human, PBMCs, T cells.
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TWEAK induces angiogenesis and proliferation of endothelial cells.
Lynch CN, Wang YC, Lund JK, Chen YW, Leal JA, Wiley SR.
The Journal of Biological Chemistry 1999 Mar; 274(13):8455.
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TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.
Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL.
The Journal of Biological Chemistry 1997 Dec; 272(51):32401.
Application:Flow Cyt, IP, Recombinant protein.
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The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.
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