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Last updated: 2016/11/27
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HRK polyclonal antibody

  • Catalog # : PAB12959
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of HRK.
  • Immunogen:
  • A synthetic peptide corresponding to internal region 15 amino acids of human HRK.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (2.5-5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of HRK in mouse pancreas tissue lysate with HRK polyclonal antibody (Cat # PAB12959) at (A) 2.5 and (B) 5 ug/mL .
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 8739
  • Gene Name:
  • HRK
  • Gene Alias:
  • DP5,HARAKIRI
  • Gene Description:
  • harakiri, BCL2 interacting protein (contains only BH3 domain)
  • Gene Summary:
  • Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. [provided by RefSeq
  • Other Designations:
  • BCL2-interacting protein,activator of apoptosis Hrk,death protein 5,harakiri
  • Related Disease
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