HRK polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of HRK in mouse pancreas tissue lysate with HRK polyclonal antibody (Cat # PAB12959) at (A) 2.5 and (B) 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HRK.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human HRK.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2.5-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HRK in mouse pancreas tissue lysate with HRK polyclonal antibody (Cat # PAB12959) at (A) 2.5 and (B) 5 ug/mL . -
Gene Info — HRK
Entrez GeneID
8739Protein Accession#
NP_003797Gene Name
HRK
Gene Alias
DP5, HARAKIRI
Gene Description
harakiri, BCL2 interacting protein (contains only BH3 domain)
Omim ID
603447Gene Ontology
HyperlinkGene Summary
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. [provided by RefSeq
Other Designations
BCL2-interacting protein|activator of apoptosis Hrk|death protein 5|harakiri
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Disease
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Publication Reference
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Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.
Cell Death and Differentiation 2000 Jan; 7(1):2.
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Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death.
Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T, Tohyama M.
The Journal of Biological Chemistry 1997 Jul; 272(30):18842.
Application：IP, WB-Tr, Insect, Sf21 cells.
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harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).
Inohara N, Ding L, Chen S, Nunez G.
The EMBO Journal 1997 Apr; 16(7):1686.
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Cell death in the third millennium.
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