LAMP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of LAMP2 in HepG2 cell lysate with LAMP2 polyclonal antibody (Cat # PAB12956) at (A) 1 and (B) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of LAMP2 in HepG2 cells with LAMP2 polyclonal antibody (Cat # PAB12956) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LAMP2.
Immunogen
A synthetic peptide corresponding to the internal regio 17 amino acids of human LAMP2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
LAMP-2 antibody is human and mouse reactive. Despite its predicted size, LAMP-2 migrates at 115KDa in SDS-PAGE.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LAMP2 in HepG2 cell lysate with LAMP2 polyclonal antibody (Cat # PAB12956) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of LAMP2 in HepG2 cells with LAMP2 polyclonal antibody (Cat # PAB12956) at 10 ug/mL . -
Gene Info — LAMP2
Entrez GeneID
3920Protein Accession#
NP_054701Gene Name
LAMP2
Gene Alias
CD107b, LAMPB, LGP110
Gene Description
lysosomal-associated membrane protein 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq
Other Designations
OTTHUMP00000023943|OTTHUMP00000023944|lysosome-associated membrane protein 2
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Interactome
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Pathway
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Disease
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Publication Reference
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High Prevalence of Autoantibodies to hLAMP-2 in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
Kain R, Tadema H, McKinney EF, Benharkou A, Brandes R, Peschel A, Hubert V, Feenstra T, Sengolge G, Stegeman C, Heeringa P, Lyons PA, Smith KG, Kallenberg C, Rees AJ.
Journal of the American Society of Nephrology 2012 Mar; 23(3):556.
Application：IF, Hamster, ldlD cells.
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Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A.
Oncogene 2004 Apr; 23(16):2891.
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Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y.
Journal of Cellular Biology 2000 Sep; 150(6):1507.
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Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.
Granger BL, Green SA, Gabel CA, Howe CL, Mellman I, Helenius A.
The Journal of Biological Chemistry 1990 Jul; 265(20):12036.
Application：IF, Mouse, NIH/3T3 cells.
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High Prevalence of Autoantibodies to hLAMP-2 in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
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