RPS6KA1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of RPS6KA1 in Jurkat cell lysate with RPS6KA1 polyclonal antibody (Cat # PAB12946) at (A) 2.5, (B) 5 and (C) 10 ug/mL .
Immunocytochemistry
Immunocytochemistry of RPS6KA1 in Jurkat cells with RPS6KA1 polyclonal antibody (Cat # PAB12946) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RPS6KA1.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human RPS6KA1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RPS6KA1 in Jurkat cell lysate with RPS6KA1 polyclonal antibody (Cat # PAB12946) at (A) 2.5, (B) 5 and (C) 10 ug/mL .Immunocytochemistry
Immunocytochemistry of RPS6KA1 in Jurkat cells with RPS6KA1 polyclonal antibody (Cat # PAB12946) at 10 ug/mL . -
Gene Info — RPS6KA1
Entrez GeneID
6195Protein Accession#
AAC82497Gene Name
RPS6KA1
Gene Alias
HU-1, MAPKAPK1A, RSK, RSK1
Gene Description
ribosomal protein S6 kinase, 90kDa, polypeptide 1
Omim ID
601684Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000004113|S6K-alpha 1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase, 90kD, 1|ribosomal protein S6 kinase, 90kD, polypeptide 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Signaling by target of rapamycin proteins in cell growth control.
Inoki K, Ouyang H, Li Y, Guan KL.
Microbiology and Molecular Biology Reviews: MMBR 2005 Mar; 69(1):79.
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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.
Manning BD.
The Journal of Cell Biology 2004 Nov; 167(3):399.
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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM.
PNAS 1998 Feb; 95(4):1432.
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Signaling by target of rapamycin proteins in cell growth control.
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